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| Product Name | Eicosanoyl-5-hydroxytyptamide |
| Description |
A neuroprotective natural product found in coffee |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | N/A |
| Molecular Formula | C30H50N2O2 |
| Molecular Weight | 470.7 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (30 mg/ml); or ethanol (20 mg/ml, warm) |
| Source | Synthetic |
| Appearance | Beige powder |
| Safety Phrases |
Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | Eicosanoyl-5-hydroxytyptamide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-615) |
Biological Description
| Alternative Names | Eicosanoyl serotonin; Eicosanoyl-5-hydroxytryptamide; EHT |
| Research Areas | Alzheimer's Disease, Neurodegeneration, Neuroscience, Synuclein, Tangles & Tau |
| Scientific Background | A natural product found in coffee which synergizes with caffeine in protecting the brain in models of alpha-synucleinopathy (1). It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated alpha-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. It prevents ABeta-induced impairments in mouse models of Alzheimer’s disease (2,3). |
| References |
1. Yan R., et al. (2018) Proc. Natl. Acad. Sci. USA . 115:E12053 2. Asam K., et al. (2017) PLoS One. 12:e0189413 3. Basurto-Islas G., et al. (2014) Neurobiol. Aging. 35:2701 |
Product Images
Chemical structure of Eicosanoyl-5-hydroxytyptamide (SIH-615), a A neuroprotective natural product found in coffee. CAS #: N/A. Molecular Formula: C30H50N2O2 . Molecular Weight: 470.7 g/mol.
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